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open question

What determines whether aggregates are cleared by UPS vs. autophagy?

Open Question open Wiki: proteins-ubc-protein
What determines whether aggregates are cleared by UPS vs. autophagy?
Importance Elo
1500
Field Rank
Rank #449 in proteins
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page proteins-ubc-protein
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Evidence Bearing On This Question
VCP-Mediated Autophagy Enhancement
candidate answer · hypothesis · 82%
TREM2-Mediated Selective Aggregate Clearance Pathway
partial answer for · hypothesis · 60%
APOE-Dependent Autophagy Restoration
bears on question · hypothesis · 55%
Autophagosome Maturation Checkpoint Control
bears on question · hypothesis · 45%
Transcriptional Autophagy-Lysosome Coupling
bears on question · hypothesis · 40%
Pairwise Tournament History
No pairwise judgments recorded yet.
Derived Hypotheses And Proposals
APOE-Dependent Autophagy Restoration
hypothesis | bears_on_question
TREM2-Mediated Selective Aggregate Clearance Pathway
hypothesis | partial_answer_for
Autophagosome Maturation Checkpoint Control
hypothesis | bears_on_question
Transcriptional Autophagy-Lysosome Coupling
hypothesis | bears_on_question
VCP-Mediated Autophagy Enhancement
hypothesis | candidate_answer
Related Entities
proteins
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