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open question

Can we develop substrate-selective inhibitors that spare essential BACE1 functions?

Open Question open Wiki: mechanisms-app-bace1-fe65-complex
Can we develop substrate-selective inhibitors that spare essential BACE1 functions?
Importance Elo
1500
Field Rank
Rank #1197 in mechanisms
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page mechanisms-app-bace1-fe65-complex
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Evidence Bearing On This Question
Palmitoylation-Targeted BACE1 Trafficking Disruptors
bears on question · hypothesis · 45%
Phase-Separated Organelle Targeting
bears on question · hypothesis · 40%
Pairwise Tournament History
No pairwise judgments recorded yet.
Derived Hypotheses And Proposals
Palmitoylation-Targeted BACE1 Trafficking Disruptors
hypothesis | bears_on_question
Phase-Separated Organelle Targeting
hypothesis | bears_on_question
Related Entities
mechanisms
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