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open question
Why are females less severely affected?
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Wiki: genes-arhgef9
Why are females less severely affected?
Importance Elo
1500
Field Rank
Rank #1487 in genes
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page genes-arhgef9
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Evidence Bearing On This Question
Sex Differences in Alzheimer's Disease — mechanisms and therapeutic implications
candidate answer
· experiment · 88%
KEEPS Continuation: Long-term effects of menopausal hormone therapy on AD biomarkers
partial answer for
· experiment · 68%
Sex differences in CB1R-mediated cannabinoid analgesia in neuropathic pain
partial answer for
· experiment · 55%
Reproductive fitness analysis of psychiatric disorders in Swedish population
partial answer for
· experiment · 52%
Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippocampal CA1 Neurons
partial answer for
· hypothesis · 48%
Complement-Mediated Synaptic Pruning Dysregulation
partial answer for
· hypothesis · 45%
Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neurons Degenerate
bears on question
· experiment · 42%
TREM2-Dependent Microglial Senescence Transition
partial answer for
· hypothesis · 42%
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Derived Hypotheses And Proposals
Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippocampal CA1 Neurons
hypothesis | partial_answer_for
Complement-Mediated Synaptic Pruning Dysregulation
hypothesis | partial_answer_for
TREM2-Dependent Microglial Senescence Transition
hypothesis | partial_answer_for
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genes
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