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open question

Population selection**: Should therapy target all PD, only LRRK2 mutation carriers, or all with elevated LRRK2 activity?

Open Question open Wiki: mechanisms-lrrk2-kinase-pathway-parkinsons
Population selection**: Should therapy target all PD, only LRRK2 mutation carriers, or all with elevated LRRK2 activity?
Importance Elo
1500
Field Rank
Rank #1151 in mechanisms
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page mechanisms-lrrk2-kinase-pathway-parkinsons
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Evidence Bearing On This Question
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown
candidate answer · experiment · 92%
AAV Serotype Comparison for LRRK2 Knockdown in PD
candidate answer · experiment · 90%
AAV-LRRK2 IND-Enabling Study Design
candidate answer · experiment · 88%
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
candidate answer · experiment · 88%
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develop PD
partial answer for · experiment · 78%
Combination Therapy Sequencing in Parkinson's Disease
bears on question · experiment · 45%
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