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LRRK2-RAB7L1 axis**: What is the precise phosphorylation site and downstream effect?
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Wiki: genes-rab7l1
LRRK2-RAB7L1 axis**: What is the precise phosphorylation site and downstream effect?
Importance Elo
1500
Field Rank
Rank #1443 in genes
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page genes-rab7l1
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Evidence Bearing On This Question
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown
bears on question
· experiment · 80%
AAV-LRRK2 IND-Enabling Study Design
bears on question
· experiment · 75%
Lysosomal Enzyme Trafficking Correction
bears on question
· hypothesis · 65%
Lysosomal Positioning Dynamics Modulation
bears on question
· hypothesis · 60%
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
bears on question
· hypothesis · 55%
Transcriptional Autophagy-Lysosome Coupling
bears on question
· hypothesis · 55%
RAB27A-dependent extracellular vesicle engineering for mitochondrial cargo delivery
bears on question
· hypothesis · 50%
Subcellular localization analysis of protein interactions
bears on question
· experiment · 50%
TBK1-PAK1IP1-PAK1 signaling pathway analysis
bears on question
· experiment · 40%
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Derived Hypotheses And Proposals
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
hypothesis | bears_on_question
RAB27A-dependent extracellular vesicle engineering for mitochondrial cargo delivery
hypothesis | bears_on_question
Lysosomal Enzyme Trafficking Correction
hypothesis | bears_on_question
Transcriptional Autophagy-Lysosome Coupling
hypothesis | bears_on_question
Lysosomal Positioning Dynamics Modulation
hypothesis | bears_on_question
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