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Are the early-phase cellular responses (inflammatory microglia, reactive astrocytes, remyelination by OPCs) adaptive protective mechanisms that eventually fail, or are they already pathogenic drivers

Open Question open paper: 39402379
Are the early-phase cellular responses (inflammatory microglia, reactive astrocytes, remyelination by OPCs) adaptive protective mechanisms that eventually fail, or are they already pathogenic drivers of progression?
Importance Elo
1500
Field Rank
Rank #3 in immunology
Tractability
0.60
Potential Impact
0.90
Evidence Summary
early phase with inflammatory microglia, reactive astrocytes, and a remyelination response by OPCs
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Related Entities
immunology
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