Does delta-catenin loss mechanistically contribute to Alzheimer's disease pathogenesis, and if so, what is the nature of its functional interaction with presenilin-1 (PS1) mutations in FAD?
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Rank #6 in neurodegeneration
Evidence Summary
Delta-catenin was first identified through its interaction with Presenilin-1 (PS1), the molecule most frequently mutated in familial Alzheimer's Disease (FAD).
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