Are the reductions in N-cadherin and PSD-95 the primary drivers of the cognitive and synaptic plasticity deficits observed in delta-cat(-/-) mice, or do they represent downstream epiphenomena?
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Rank #7 in neurodegeneration
Evidence Summary
N-cadherin and PSD-95, two proteins that interact with delta-catenin, are significantly reduced in mutant mice.
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