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paper

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.

📄 Paper Details
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.
["Henderson S", "Johnson T"]
Current biology : CB PubMed DOI
Abstract

Evolutionary models of aging propose that a trade-off exists between the resources an organism devotes to reproduction and growth and those devoted to cellular maintenance and repair, such that an optimal life history always entails an imperfect ability to resist stress. Yet, since environmental stressors, such as caloric restriction or exposure to mild stress, can increase stress resistance and life span, it is possible that a common genetic mechanism could regulate the allocation of resources ...

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