The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

📄 Paper Details

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z

Abstract

1. Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Krasemann S(1), Madore C(2), Cialic R(2), Baufeld C(2), Calcagno N(2), El Fatimy R(2), Beckers L(2), O'Loughlin E(2), Xu Y(3), Fanek Z(2), Greco DJ(2), Smith ST(2), Tweet G(2), Humulock Z(2), Zrzavy T(4), Conde-Sanroman P(5), Gacias M(5), Weng Z(6), Chen H(6), Tjon E(2), Mazaheri F(7), Hartmann K(...