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paper

Formal group insertion into aryl C‒N bonds through an aromaticity destruction-reconstruction process.

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Formal group insertion into aryl C‒N bonds through an aromaticity destruction-reconstruction process.
["Han D", "He Q", "Fan R"]
Nature communications PubMed DOI
Abstract

Given the abundance and the ready availability of anilines, the selective insertion of atoms into the aryl carbon-nitrogen bonds will be an appealing route for the synthesis of nitrogen-containing aromatic molecules. However, because aryl carbon-nitrogen bonds are particularly inert, anilines are normally activated by conversion to more reactive intermediates such as aryldiazonium salts to achieve functionalization of the aryl carbon-nitrogen bonds, but the nitrogen atom is usually not incorpora...

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