1. Nat Rev Neurol. 2019 Sep;15(9):501-518. doi: 10.1038/s41582-019-0228-7. Epub 2019 Jul 31. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Yamazaki Y(1), Zhao N(1), Caulfield TR(1), Liu CC(1), Bu G(2). Author information: (1)Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. (2)Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. bu.guojun@mayo.edu. Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant...