Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.

1. MAbs. 2020 Jan-Dec;12(1):1829334. doi: 10.1080/19420862.2020.1829334. Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice. Low BE(1), Christianson GJ(1), Lowell E(2), Qin W(2), Wiles MV(1). Author information: (1)The Jackson Laboratory , Bar Harbor, ME, USA. (2)Previously at the Jackson Laboratory , Bar Harbor, ME, USA. A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I f...