TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.

📄 Paper Details

Yu CH, Davidson S, Harapas CR, Hilton JB, Mlodzianoski MJ, Laohamonthonkul P, Louis C, Low RRJ, Moecking J, De Nardo D

Cell PubMed

Abstract

1. Cell. 2020 Oct 29;183(3):636-649.e18. doi: 10.1016/j.cell.2020.09.020. Epub 2020 Oct 7. TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS. Yu CH(1), Davidson S(1), Harapas CR(1), Hilton JB(2), Mlodzianoski MJ(3), Laohamonthonkul P(1), Louis C(1), Low RRJ(4), Moecking J(5), De Nardo D(6), Balka KR(6), Calleja DJ(1), Moghaddas F(7), Ni E(8), McLean CA(9), Samson AL(1), Tyebji S(8), Tonkin CJ(8), Bye CR(10), Turner BJ(10), Pepin G(11), Gantier MP(11), Roger...