1. Int J Mol Sci. 2021 May 28;22(11):5769. doi: 10.3390/ijms22115769. The Role of PGC1α in Alzheimer's Disease and Therapeutic Interventions. Mota BC(1), Sastre M(1). Author information: (1)Department of Brain Sciences, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. The peroxisome proliferator-activated receptor co-activator-1α (PGC1α) belongs to a family of transcriptional regulators, which act as co-activators for a number of transcription factors, incl...