1. Clin Exp Pediatr. 2022 Apr;65(4):172-181. doi: 10.3345/cep.2021.00521. Epub 2021 Oct 18. Genetic factors in precocious puberty. Shim YS(1), Lee HS(1), Hwang JS(1). Author information: (1)Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea. Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal (HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors. Most cases of preco...