IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer.

📄 Paper Details

Shigeta K, Hasegawa M, Hishiki T, Naito Y, Baba Y, Mikami S, Matsumoto K, Mizuno R, Miyajima A, Kikuchi E

Abstract

1. EMBO J. 2023 Feb 15;42(4):e110620. doi: 10.15252/embj.2022110620. Epub 2023 Jan 13. IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer. Shigeta K(1), Hasegawa M(2), Hishiki T(3)(4), Naito Y(3), Baba Y(1), Mikami S(5), Matsumoto K(1), Mizuno R(1), Miyajima A(2), Kikuchi E(1)(6), Saya H(3)(7), Kosaka T(1), Oya M(1). Author information: (1)Department of Urology, Keio University School of Medicine, Tokyo, Japan. (2)Department of Urology...