INTRODUCTION: The aryl hydrocarbon receptor (AhR) is a promising therapeutic target for ulcerative colitis (UC) and plays a role in regulating neutrophil function. OBJECTIVE: We aimed to investigate the effects and mechanisms of AhR on NETosis, a neutrophil-driven process that disrupts intestinal epithelial homeostasis, to support the development of anti-UC therapies. METHODS: A dextran sulphate sodium (DSS)-induced colitis mouse model was established, and bioinformatics analyses combined with m...