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paper

Targeting KCNN4 channels modulates microglial activation and apoptosis in a PD-relevant inflammatory model.

📄 Paper Details
Targeting KCNN4 channels modulates microglial activation and apoptosis in a PD-relevant inflammatory model.
["Hung H", "Li I", "Lin Y", "Yeh T", "Ng K", "Wang T", "Hong K", "Wang T", "Wu Y", "Shih J"]
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie PubMed DOI
Abstract

Parkinson's disease (PD) is characterized by chronic neuroinflammation and progressive dopaminergic neurodegeneration, driven primarily by the activation of microglia and associated apoptotic pathways. The intermediate-conductance calcium-activated potassium channel KCNN4 has recently emerged as a potential therapeutic target, yet its role in chronic neurodegenerative conditions remains underexplored. In this study, we investigated whether pharmacological inhibition of KCNN4 using TRAM-34 can mo...

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