ETHNOPHARMACOLOGICAL RELEVANCE: Pathological mitochondrial hyperfission and ectopic lipid deposition in renal tubules are critical contributors to the progression of diabetic kidney disease (DKD), with SUMO1-mediated modification of DRP1 functioning as a key driving mechanism. The traditional Chinese medicine formula Suoquan Yishen Formula (SQYSF) has demonstrated clinical efficacy in ameliorating DKD; however, it remains unclear whether it improves the mitochondrial-lipid metabolism network by ...