RATIONALE: Sleep disturbances are closely associated with cognitive decline and an increased risk of neurodegenerative diseases in humans. This association may be mediated by glymphatic dysfunction, which could ultimately lead to cognitive deterioration. OBJECTIVES: This review aims to provide an overview of current research on the impact of sleep on the functions of the glymphatic system. It analyzes the regulatory roles of the sleep-wake cycle and neurovascular coupling (NVC), along with molec...