Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer.

📄 Paper Details

Lin Z, Gao Y, Zhang Q, Yang S, Chen Y, Ding H, Peng W, Zhang X, Nurzat Y, Hu J

Cancer Lett PubMed DOI

Abstract

1. Cancer Lett. 2026 May 1;645:218392. doi: 10.1016/j.canlet.2026.218392. Epub 2026 Mar 2. Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer. Lin Z(1), Gao Y(2), Zhang Q(3), Yang S(3), Chen Y(3), Ding H(4), Peng W(3), Zhang X(3), Nurzat Y(3), Hu J(3), Liao W(5), Xiong B(6), Xiao M(7), Zhang X(8). Author information: (1)Department of Otolaryngol...