Objectives: To investigate the therapeutic effects of Yangxin granules (YNX), a classic traditional Chinese medicine, in acute myocardial infarction (AMI) and its underlying mechanism. Methods: Rats were subjected to left anterior descending coronary artery ligation to establish AMI. Thereafter, YNX was administered once daily for 4 weeks. Cardiac function, histopathological changes, iron deposition, oxidative stress, and ferroptosis related proteins were evaluated. RNA sequencing was performed ...