Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS.

📄 Paper Details

Filippatou AG, Gakis G, Bacchetti A, Kim A, Said Y, McCormack B, Lin TY, Didouchevski A, Pellegrini N, Fitzgerald KC, Calabresi PA, Saidha S, Sotirchos ES

Neurology(R) neuroimmunology & neuroinflammation PubMed DOI

Abstract

BACKGROUND AND OBJECTIVES: Optic neuritis (ON) is a common manifestation of multiple sclerosis (MS), aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder (AQP4+NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Compared with MS-ON, AQP4-ON and MOGAD-ON eyes exhibit more severe thinning of the macular composite ganglion cell + inner plexiform layer (GCIPL), as measured by optical coherence tomography (OCT). The individual measurement of the ganglio...