BACKGROUND: Duzhong-Gegen formula (DGF) is prepared by decoction of Eucommia ulmoides Oliv. (Du Zhong in Chinese), Pueraria montana Merr. (Ge Gen), Zea mays l. (Yu Mi Xu) and Citrus reticulata Blanco (Chen Pi), which are all edible herbs widely used in China for thousands of years. However, whether DGF exhibits ameliorating effects on hyperuricemia (HUA) remains unclear. PURPOSE: This study was designed to investigate the effects and underlying mechanism of DGF on HUA in mice. METHODS: HUA was i...