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paper

BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/SMAD3 in TGF-β1 pathway.

📄 Paper Details
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/SMAD3 in TGF-β1 pathway.
Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wang Y
Biochemistry and biophysics reports PubMed DOI
Abstract

Cardiac function is markedly impaired as a result of myocardial fibrosis, a major pathological consequence that develops after myocardial infarction (MI). While BMAL1 (Brain and Muscle ARNT-like protein 1), a core circadian rhythm regulator, has been implicated in various cardiovascular pathologies, its role in post-MI cardiac fibrosis remains unclear. This study aimed to elucidate the role and underlying molecular mechanisms of BMAL1 in cardiac fibrosis. MI was induced in mice by permanent liga...

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