BACKGROUND: Calcium oxalate calculi constitute the predominant form of kidney stones, yet the molecular pathways governing their formation are not fully understood. Growing evidence suggests that these crystalline deposits can trigger apoptotic pathways in renal tubular epithelial cells. Within this pathological context, various amino acid metabolic pathways significantly influence cellular viability. This study seeks to elucidate the involvement of serine metabolism in endoplasmic reticulum str...