BACKGROUND: The role of ferroptosis in Cardiac arrest (CA)-induced cerebral edema remains unclear. PURPOSE: To investigate whether ferroptosis contributes to blood-brain barrier (BBB) disruption and aquaporin-4 (AQP4) dysfunction following CA. STUDY TYPE: Prospective. ANIMAL MODEL: Asphyxia-induced CA rat model. Forty two rats were used and assigned to the CA (24) and the sham (18) group. FIELD STRENGTH/SEQUENCE: T2-weighted anatomical imaging with 2D turbo spin-echo sequence, QSM with 3D GRE se...