Diabetic kidney disease (DKD) is characterized by renal lipid deposition, andlipotoxicity-induced ferroptosis plays a pivotal role in its progression. This study aimed to elucidate the regulatory mechanism of silent information regulator 1 (SIRT1) in lipotoxicity-induced ferroptosis in DKD using clinical samples, animal models, and cellular experiments. Renal tissues from DKD patients and non-diabetic controls were collected for pathological and molecular analyses. DKD mouse model was establishe...