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paper

Whole-genome sequencing reveals an East Asian-specific rare variant of INPP5J associated with Alzheimer's disease.

📄 Paper Details
Whole-genome sequencing reveals an East Asian-specific rare variant of INPP5J associated with Alzheimer's disease.
Kimura T, Yamakawa A, Mitsumori R, Niida S, Ozaki K et al.
Transl Psychiatry PubMed DOI
Abstract

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly, yet no curative treatments are available. Although genome-wide association studies (GWASs) have identified numerous genetic risk factors, these factors often differ among ethnic groups, and the mechanisms driving LOAD onset remain poorly understood. Most GWASs of LOAD have been conducted in European populations; the expansion of future studies to non-European populations should uncover novel genetic factors...

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