INTRODUCTION: Malignant tumors currently pose a significant threat to global health. Tumor progression is jointly regulated by genetic mutations and the mechanical properties of the tumor microenvironment (TME), including increased tissue stiffness, elevated fluid pressure, and mechanical compression experienced by circulating tumor cells (CTCs) within microvessels. These mechanical signals are transmitted through mechanosensitive pathways, with the Piezo channel family (Piezo1/Piezo2) serving a...