Fig. 11Figure 11
Effect of AMI treatment on intestinal barrier disruption and subsequent serum LPS levels associated with tauopathy in P301S mice. ( a ) Photomicrographs showing the expression of claudin-1 and ZO-1 tight junction proteins in distal colon in the three experimental groups (400X scale bar = 50 μm). ( b ) A graph showing the percentage area of immunostaining for claudin-1 tight junction protein in distal colon in the three experimental groups. ( c ) A graph showing the percentage area of immunostaining for ZO-1 tight junction protein in distal colon in the three experimental groups. ( d ) serum LPS levels in the three experimental groups All data are presented as a mean ± SD. ( n = 6). One-way analysis of variance (ANOVA) was used to determine statistical significance, followed by Tukey’s multiple comparison analysis. A p-value below 0.05 was considered significant where *p ≤ 0.05, **p ≤ 0.005, ***p ≤ 0.001, ****p ≤ 0.001