Fig. 10Figure 10
DAPK1 inhibition ameliorates emotional and cognitive impairments in a mouse model of tauopathy. ( A-B) The Y-maze test was applied to evaluate the short-term memory ability in mice treated with or without C6. The number of NA entry and the percentage of time spent in NA for each group are presented. n = 9–11 mice/group. (C-F) The open field test (OFT) was employed to analyze the anxiety-like behavior in mice treated with or without C6. Representative movement trajectories ( C ) for each group are shown. The blue square indicates the center area in OFT. The total ambulatory distance ( D ), the percentage of time spent ( E ) and distance traveled ( F ) in the center area are presented. n = 10–12 mice/group. (G-H) A novel object recognition (NOR) test ( G ) was performed to evaluate the preference toward novel object ( H ) in mice treated with or without C6. n = 10–12 mice/group. (I-M) Mice were subjected to the MWM test to assess spatial learning and memory abilities. The me