Fig. 10Figure 10
The LF3 treatment reversed the expression of Wnt3/β-catenin/TCF4 signaling pathway, TJs and AJs proteins. A Western blot detected the Wnt/β-catenin/TCF4 signaling proteins expression levels in the hippocampus after LF3 treatment (n = 6). B – F The quantification analysis of Wnt/β-catenin/TCF4 signaling proteins expression levels after LF3 treatment (n = 6). G Western blot detected the TJs and AJs proteins expression levels in the hippocampus after LF3 treatment (n = 6). H – M The quantification analysis of TJs and AJs proteins expression levels after LF3 treatment (n = 6). NETs: Neutrophil extracellular traps; CLP: Cecal Ligation and Puncture; SAE: Sepsis-associated encephalopathy; BBB: Blood–brain barrier; TJs: Tight junctions; AJs: adherens junction (ns: no significance, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)