Fig. 3Figure 3
Distinct transcriptional signature between CLP- and GSK484-treated hippocampus. A A vulcano plot was depicted with p < 0.05 of all 705 detected genes from RNA-Seq dataset. Differential expression genes (DEGs) were colored with blue and red, regarding to 163 down-regulated and 542 up-regulated genes, respectively. B Bar plot of GO enrichment analysis; (BP) biological process, (CC) cellular components, (MF) molecular function. C Bubble plot of KEGG pathway analysis. D Cytoscape was used to visualize the PPI network generated by String. E The top 10 hub genes were obtained using the CytoHubba plug-in in Cytoscape. F The top 1 modules are presented based on MCODE scores in descending order. DEGs: Differential expression genes; BP: biological process; CC: cellular components; MF: molecular function; CLP: Cecal Ligation and Puncture; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes