Fig. 8Figure 8
The inhibition of NETs formation alleviated the AJs disruption may by regulating VCL/β-catenin/VE-cadherin functional complex. A Triple labeling IF staining showed colocalization of VCL, β-catenin and VE-cadherin (n = 6); Quantification of the fluorescence intensity of VCL ( B ), β-catenin ( C ) and VE-cadherin ( D ) in the hippocampus (n = 6). NETs: Neutrophil extracellular traps; CLP: Cecal Ligation and Puncture; SAE: Sepsis-associated encephalopathy; IF: immunofluorescence. (ns: no significance, * p < 0.05, ** p < 0.01, *** p < 0.001)