Figure 1.Figure 1
Alpha-synuclein proteoforms in the appendix and substantia nigra (SN) (A) Bar plot showing 65 alpha-synuclein proteoforms identified in the human appendix and SN. Acetylated proteoforms are colored dark blue; unacetylated proteoforms are colored light blue. Nine proteoforms, which were only found in the appendix, are denoted with *. (B) Bar plot showing alpha-synuclein proteoforms distribution according to their abundance in the human appendix and SN separately. X-axis shows the percentage of the abundance for each existing proteoform. Top 5 most abundant proteoforms are listed with their color codes. (C) Common alpha-synuclein and rare proteoforms showing tissue differences. For common alpha-synuclein proteoforms, robust linear regression was used for statistical analysis adjusting for diagnosis (synucleinopathy/control) and age, with proteoform abundance as dependent variable (Y) and tissue as independent variable (X). Proteoforms showing significant tissue differences after FDR