Figure 2Figure 2
Multifaceted mechanisms of mAbs against bacterial infections. This figure illustrates the complex mechanisms through which mAbs counteract bacterial infections. ( A ) Highlights the neutralization or inhibition of bacterial virulence factors by mAbs, mitigating their pathogenic effects. ( B ) The process of mAbs blocking receptor-mediated adhesion is depicted, preventing bacterial adherence to host cells and hindering the progression of infection. ( C ) Portrays the Antibody–Antibiotic Conjugate (ADC) strategy, where mAbs conjugated with antibiotics enhance the precision and effectiveness of bacterial targeting and elimination. ( D ) Focuses on the role of mAbs in inhibiting or disrupting biofilm formation, a primary bacterial defense mechanism, facilitating bacterial clearance. ( E ) Illustrates the mAb-mediated NETosis/opsonophagocytosis pathway, promoting bacterial clearance through the facilitation of neutrophil extracellular traps (NETs) and enhanced phagocytosis. ( F ) Delineates