Fig. 2Figure 2
AXL, MERTK, or AM deleted mice were vulnerable to JEV attack with aggravated neuroinflammation. A . AXL −/− , MERTK −/− , AM −/− , and WT mice were infected with JEV at 10 6 PFU. The survival rates of AXL −/− , MERTK −/− and AM −/− mice were all 0%, and that of WT mice was 36%. The median survival times of AXL −/− , MERTK −/− , AM −/− , and WT mice were 5.5, 7.5, 8, and 12 days respectively. B . AXL −/− , MERTK −/− , AM −/− , and WT mice were infected with JEV at 10 5 PFU; the survival proportions of AXL −/− , MERTK −/− , and AM −/− mice were 6.67%, 0%, and 14.29%, while that of WT mice was 38.46%; the median survival times were 7.5, 11, 9, and 15 days, respectively. AXL −/− and WT mice were infected with JEV at 10 6 PFU, and the brains from each group were harvested for HE staining and proinflammatory cytokine detection at 3 and 5 dpi. C . Histopathological changes in the meninges and cerebral cortex in each group. The meninges thickened after JEV infection, as indicated by