Fig. 3Figure 3
Characterization, efficient drug loading and responsive drug release of MN patches. a Force curve of MN patches with different crosslinking time. Arrows indicate fracture force. b Swelling ratios of MNs with different crosslinking time. c Drug loading amount of 5-FuA prepared from various concentrations of drug loading solutions. d Crosslinking efficiency of MNs with different crosslinking time. e Enzymatic degradation of GelMA with different crosslinking time. f SEM images of MN patches before (left) and after (right) enzymatic degradation ( n = 3 independent experiments). g ROS-responsive cleavage of 5-FuA-Pep-MA prodrug incubated with different concentrations of H 2 O 2 . h Drug release curves of dual responsiveness drug delivery platform with different crosslinking time. The data in ( b–e ), ( g , h ) are presented as mean ± SD ( n = 3 independent experiments). The data were analyzed by t -test. P- value: *** P < 0.001.