Figure 6Figure 6
Prediction of PDGFR as a possible off-target of torcetrapib. ( A ) Docked complex of PDGFR (PDB code 1GQ5) and crenolanib in the best docking pose. ( B ) Docked complex of PDGFR and torcetrapib in the best docking pose. Crenolanib and torcetrapib were in the stick representation, whilst the amino acid residues of PDGFR were displayed by solid ribbon style in the line representation. C, H, O, N and F were colored with gray, white, red, blue and brown, respectively.