Figure 2Figure 2
Multistep and multiscale model of MiT family-driven renal cell carcinoma. Schematic overview linking initiating genetic events ( TFE3 gene fusions or TFEB gene amplification/rearrangement) to MiT-driven transcriptional reprogramming, cellular consequences, characteristic morphologic patterns, and downstream clinical implications. The diagram integrates molecular alterations with diagnostic pitfalls, clinical heterogeneity, and current therapeutic uncertainty. Arrows indicate progression/relationships between molecular alterations, cellular consequences, tumor phenotype, and clinical implications; colors and icons are schematic and not quantitative. Created in BioRender. Cotaina Recio, M. (2026) https://BioRender.com/8vz33mn (accessed on 12 March 2026).