Figure 3Figure 3
APOE function on lipid metabolism. APOE gene plays a central role in lipid metabolism, particularly in the binding and transport of lipids such as cholesterol and phospholipids to neuronal membranes, contributing to neuronal plasticity. ApoE function is influenced by oxidative stress, neuroinflammation, and mitochondrial dysfunction, which contribute to the development of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, stroke, and TBI. Created with Canva. APOE: Apolipoprotein E gene; TBI: traumatic brain injury.