Fig. 2Figure 2
Cross-GSG comparison of multi-GSG GWAS associations. Shown are results for 18 loci associated with AD risk within and across multiple ancestries. Circle size corresponds to the significance level, − log 10 ( P -value), and circle color represents the significance threshold: red, P < 5 × 10 −8 ; orange, 0.05 > P > 5 × 10 −8 ; and blue, P > 0.05. Arrows represent the direction of effect of the risk allele, with “up” indicating increased risk and down decreased risk. Asterisks (“*”) indicate the association was found in APOE ε4-adjusted models