Figure 1Figure 1
Expression of resolvin receptors ALX and ChemR23 in human osteoarthritis (OA) joint tissue. A and B, Transformed C t values for resolvin receptors ALX and ChemR23 mRNA in synovium ( A ) and medial tibial plateau ( B ) specimens obtained from patients with end‐stage OA. Expression of ChemR23 was significantly higher than that of ALX in both OA synovium (n = 15 specimens) ( A ) and medial tibial plateau (n = 14 specimens) ( B ), as shown by a larger transformed C t value (maximum cycle number for run – cycle number at which exponential amplification occurs). Bars show the mean ± SEM. ∗∗∗∗ = P < 0.0001 by unpaired t ‐test. C–F, Correlations of ALX and ChemR23 with the cytokine interleukin‐6 (IL‐6) and the enzyme 15‐lipoxygenase 1 (15‐LOX‐1) in human medial tibial plateau tissue. G–J, Correlations of ALX and ChemR23 with IL‐6 and 15‐LOX‐1 in human synovium.