Figure 2Figure 2
Expression of resolvin receptors ALX and ChemR23 in rat osteoarthritis (OA) joint tissue. A and B, Significant weight‐bearing asymmetry ( A ) and decreased ipsilateral paw withdrawal thresholds ( B ) following intraarticular injection of monosodium iodoacetate (MIA) into the knee joints (MIA‐treated rats) compared with saline‐treated control rats (n = 8 per group). Values are the mean ± SEM. ∗∗∗∗ = P < 0.0001 versus control, by two‐way analysis of variance with Bonferroni's post hoc test. C and D, Decreased synovial expression of ChemR23 in MIA‐treated rats compared with saline‐treated control rats on day 14 ( C ) and day 35 ( D ). E and F, Comparable expression of ALX in the synovium of MIA‐treated rats and saline‐treated rats on day 14 ( E ) and day 35 ( F ) (n = 7–8 per group). Bars in C – F show the mean ± SEM. ∗ = P < 0.05; ∗∗ = P < 0.01 by unpaired t ‐test.