Fig. 7Figure 7
C1q -deficiency delays loss of visual function due to retinal I/R. ( a ) Representative ERG traces observed in WT mice comparing waveforms from ischemic and uninjured eyes across a series of flash intensities tested 28 days post injury. ( b ) Comparison of b-wave amplitudes over a 28 day time course at an intensity of 3000 mcd.s/m 2 . A statistically significant loss of b-wave response was observed in WT ( p < 0.01) and C1qa
+/- ( p < 0.05) ischemic eyes compared to uninjured controls at all time points. However, following initial b-wave suppression, C1qa
-/- ischemic eyes displayed a significant rescue ( p < 0.05) on day 14. This rescue was transient as a slight decline was observed over the remaining two time points; by the end no statistical differences were observed between any animals receiving ischemic injury. Mean ± SEM, n = 8 per group. * p < 0.05 ** p < 0.01 *** p < 0.001 compared to control # p < 0.05 comared to WT–I/R determined by One-way ANOVA followed by