Cross-disease Cures Portfolio: 15 targets × 4 verticals

💼 PortfolioCross-disease Cures Portfolio

cross_disease_curemultiplier 1.5×

Target genes (15)

TREM2 implicated across 10 disease verticals: Alzheimer's disease (alzheimers), Alzheimer's Disease (alzheimers), biomarkers, clinical neurology, connectomics, developmental neurobiology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation), neuroscience, synaptic biology

CX3CR1

CX3CR1 implicated across 5 disease verticals: biomarkers, connectomics, developmental neurobiology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

NLRP3

NLRP3 implicated across 5 disease verticals: clinical neurology, developmental neurobiology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation), Neuroinflammation (neuroinflammation)

SPP1

SPP1 implicated across 3 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation), synaptic biology

TFEB

TFEB implicated across 3 disease verticals: neurodegeneration (alzheimers), Neuroinflammation (neuroinflammation), proteomics

C1Q

C1Q implicated across 3 disease verticals: molecular biology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

P2RY12

P2RY12 implicated across 3 disease verticals: developmental neurobiology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

TBK1

TBK1 implicated across 3 disease verticals: ALS (als), neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

SIRT3

SIRT3 implicated across 3 disease verticals: Alzheimer's Disease (alzheimers), neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

PINK1

PINK1 implicated across 2 disease verticals: neurodegeneration (alzheimers), Neuroinflammation (neuroinflammation)

TREM2/TYROBP

TREM2/TYROBP implicated across 2 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

SNCA

SNCA implicated across 2 disease verticals: neurodegeneration (alzheimers), Parkinson's disease (parkinsons)

APOE4

APOE4 implicated across 2 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

GPX4

GPX4 implicated across 2 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

HIF1A

HIF1A implicated across 2 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)

Diseases covered (15)

Alzheimer's diseasebiomarkersParkinson's diseaseconnectomicsNeuroinflammationneuroscienceAlzheimer's DiseaseneuroinflammationneurodegenerationALSsynaptic biologymolecular biologyproteomicsdevelopmental neurobiologyclinical neurology

Upstream targets

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