TREM2 Ectodomain Variant — Binding-Optimized

🧬 Protein Design

Method

Rosetta Interface Design

Stability

88%

Binding (Kd)

120 nM

pLDDT

0.89

ΔG

-1.8 kcal/mol

MUTATIONS (5)

T96SK186RA192VH157YR62W

Sequence (278 aa)

MEPLRPGWLLLVSLAQVALGGPPPGPRPGLWAWEGRVREGPRLPAAGTAVPPPGAVWQLEDGRTMCFARHGPLSLGADVAAVSWLRGAVGRGLAAAVLLAVALLVLWLTRRAGRSRKDTIEVPVEEPPHVFVVFTDADTHPKELLLFCTQSDLCFQAQQSVHQWAEFNGSSVVPDCCHPLHPGSSLVGALLREPQEVLLHRLPDAIQGLSLVIKDVQEGDMFHCVWQDWGMPSPQMPQQVEPAYHPKVFAGQVMVTQCVQHDCFALRQPSGREPDHPG

Interface residue optimization for enhanced Aβ oligomer recognition. Slight stability trade-off accepted for 6.5x binding improvement.

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

Rotate: click+drag | Zoom: scroll | Reset: right-click