TREM2 Ectodomain Variant — Binding Optimized

🧬 Protein Design

Method

Rosetta Interface Design

Stability

88%

Binding (Kd)

120 nM

ΔG

-1.8 kcal/mol

MUTATIONS (5)

T96SK186RA192VH157YR62W

Sequence (174 aa)

MEPLRPPGAWVLlalllgsaegstceedvddtfldtafqgvltfqrgdsvvtgalhcqptarcqmssqeqtlyqkvslyvragkrarvqgipvsvgeggmlhlidylafavnmskgtytegllayceesssspmsahpprarlvkfhlpptttvqvlpqfqklpetggslvylv

Interface optimization for 6.5x binding improvement

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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